---

About the Nonprofit

Visit Our Website

PRISMS is an advocacy, education, and support organization for individuals with Smith-Magenis Syndrome (SMS), their families, and the professionals who serve them. PRISMS is a nonprofit 501(c)(3) organization formed on February 4, 1993 by a group of parents and professionals with a desire to build education, awareness, and research opportunities for all those affected by SMS.

Smith-Magenis Syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11.2, which contains the gene RAI1.

SMS is a rare disorder that occurs in between 1 out of every 15,000 to 25,000 births. Although the number of individuals diagnosed with SMS has increased in recent years due to better diagnostic tools, the syndrome likely remains underdiagnosed.

PRISMS is working with the global SMS community to build a future of hope.